It acts on µ-receptors and enhance their activity. It has been used as a pain reliever for postoperative pain. It is a popular analgesic and one of the most preferred drugs in the pain-killer category. The dosage of Tramadol in cases of management of postoperative pain depends on the severity and duration of pain.

The analgesic effect produced by a single 100 mg oral dose of tramadol is same as produced by 1000 mg Paracetamol. A study was done to evaluate the pharmacological effect of Tramadol and in this it was found that at least 50% of patients got respite from moderate to severe pain (4-5 hours) as compared with placebo. 



Tramadol acts in two ways. It not only binds to the opioid receptors but also blocks the reuptake of inhibits serotonin and nor-epinephrine. This unique mechanism of action allows tramadol to manage acute and chronic pain in a safe and efficient way. Acute pain is sharp and short-duration pain whereas chronic pain is high intensity and long-duration pain.


Tramadol is successful in treating acute pain conditions such as labor pain without respiratory depression of the neonate, acute trauma, myocardial ischemia and pain in the uterus. The use of Tramadol for a long duration of time can lead to addiction. Hence, the extended use of this drug should be avoided.


The possibility for abuse or habit-forming seems to be less and serious complications have not been reported. The dosage of tramadol in adults is 50 mg to 100 mg (according to the intensity of pain) every 4 to 6 hours. The maximum dose should not exceed 400 mg per day. In case of extended release formulation, the maximum dose should not exceed 300mg per day. 


Tramadol is used in effective management of cancer pain. The dose may vary. Do not put an end to the use of this drug suddenly as it can lead to withdrawal symptoms such as stomach cramps, sleep deprivation, mild headache, nausea etc. Concomitant use of other narcotic analgesics with this drug can lead to severe interactions.


The dose of Tramadol in geriatric patients is one to two capsules every nine hours. The dose of Tramadol is one to two capsules every twelve hours in case of patients suffering from kidney or liver disorders. The maximum dose should not exceed 300mg per day in both the cases.


Tramadol is also used in the management of pain in pediatrics. But proper precautions should be taken in the above case to avoid harmful effects. Tramadol can have some side effects such as illness, heartburn, backache, dizziness, allergic reactions, headache temporary loss of vision and coordination, pain in the chest, anxiety and strain, etc. These side-effects do not last longer and may even not occur in few patients.


Safety tips:-

  • If you have suffered from any recent cardiovascular problem, then use this drug with precaution; 
  • You should take this medicine with extra care, in case of lactation and pregnancy;
  • You should avoid driving, as it may depress your central nervous system and make you drowsy;
  • If you are hypersensitive to Tramadol or other related drugs, do not consume this medication.